The SMILES trial (Supporting the Modification of Lifestyle in Lowered Emotional States) highlighted a general healthy Mediterranean-inspired diet which focused on increasing the consumption of fruits, vegetables, lean protein, and whole grains, while decreasing the consumption of carbohydrates, sweets, and heavily processed foods.
For the study, the participants were allowed to continue the treatments for depression that they were currently doing, which mainly involved psychotherapy, antidepressant medications, or some combination of the two. This ensured that the researchers could determine the added benefit of dietary modification rather than testing the diet as a primary intervention.
The study involved 67 patients suffering from major depressive disorder which ranged from moderate to severe. They also had baseline diets that were not particularly healthy in the first place.
Half of the participants were randomly grouped into a dietary modification group which received seven sessions of personalized nutritional counseling and motivational support called "ModiMedDiet." It emphasized healthier food choices as described above. The counselors also focused on reducing alcohol consumption – they allowed a maximum of two glasses of wine per day. The rest of the participants went to a control group that had social support, which was basically friendly chats with a research assistant.
Results showed that the participants in the dietary modification group generally improved their eating habits, which in turn improved symptoms of their depression. The main instrument used to track the participants' depression severity indicated that those in the dietary modification group improved significantly more than the control group – in terms of raw scores, the mean depression score for the dietary modification group dropped from 26 to 15 over a period of 12 weeks, while the control group fell from 25 to only about 20.
This shows a fairly large effect that is comparable to some studies of antidepressant "augmentation" with other medications, such as antipsychotic agents, which are linked to some serious side effects.
By the end of the study, about a third of the participants in the dietary modification group were rated as being "in remission" from their depression symptoms compared to only eight percent in the control group. Anxiety scores also improved with the dietary modification. The improvement in depression symptoms was found to be independent of changes in weight.
The researchers acknowledge that it's still unclear how a better diet improves depression symptoms, but they note that other research suggests pathways related to decreased inflammation, antioxidant effects, and changes in a person's gut bacteria can affect brain activity.
As with any health problems, eating the right foods help manage the symptoms and even treat them. For depressive disorders, here are some foods that have been shown to improve its symptoms.
It's important to consult your healthcare provider before deciding to add a diet plan as part of your depression treatment. DO NOT stop antidepressant medications on your own.
Learn more about depression and the natural ways to improve its symptoms at BeatDepression.news.
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