The team of American researchers evaluated the ability of curcumin, which is a polyphenol in turmeric, to target cancer stem cells that are assumed to be the primary cause of cancer tumor formation and malignancy. Unlike conventional cancer models used in previous studies, the cancer stem cell model suggests that only a small population of cancer cells drive the initiation, maintenance, and growth of tumors. These stem cells regularly undergo renewal and differentiation into other cancer cells, which no longer have the ability to regenerate themselves. Therefore, in this model, cancer stem cells that are not killed by treatments lead to the formation of more invasive and treatment-resistant tumors.
In this study, the researchers found that curcumin is more effective in eradicating cancer since unlike conventional treatments, this polyphenol also targets cancer stem cells. It can do so through various mechanisms of action, which include the following.
- Regulation of cancer stem cell self-renewal pathway -- There are different pathways involved in the self-renewal of cancer stem cells. These include the Wnt/beta-catenin, sonic hedgehog 89 (SHH), and Notch pathways. The researchers found that curcumin can directly or indirectly interfere with these pathways in 12 different cancer cell lines
- Modulation of microRNA -- The body contains microRNAs, which are short RNA sequences that don't encode for anything. These microRNAs regulate more than 33 percent of protein-coding genes by targeting and binding to their corresponding messenger RNAs so that these won't be expressed. In this study, the authors observed that curcumin altered microRNA expression in cancer stem cells so that they can't produce everything that they need for tumor formation and growth.
- Direct anti-cancer activity -- Curcumin selectively targets cancer cells and programs their death. When used in conjunction with conventional anticancer agents, this effect becomes more evident and the damage typically caused by chemotherapy is no longer observed.
Overall, the results of this study show that for cancer treatments to be effective, they have to target and kill cancer stem cells just like turmeric does. Otherwise, these cancer stem cells will pave the way for the formation of more invasive and treatment-resistant tumors. (Related: Turmeric OUTPERFORMS conventional chemotherapy drugs in treating all forms of cancer.)
Other health benefits of turmeric
Some other health benefits associated with turmeric include the following:
- Boosting immunity
- Balancing hormone levels
- Preventing hair loss
- Promoting good digestion
- Detoxifying the liver
- Reducing the risk of Alzheimer's
- Relieving arthritis pain
How to get the most out of turmeric
The body does not easily absorb turmeric since it needs fat for it to dissolve and get into the gut. Some tips on how you can maximize the therapeutic potential of turmeric include the following:
- Mix turmeric with almond milk, which is rich in healthy fats, and drink up.
- Sprinkle turmeric over some avocadoes before eating them since these are rich in omega-3 fatty acids that increase absorbance.
- Combine turmeric with black pepper in salad dressings, juices, smoothies, or soups since the latter can relax the intestines so curcumin can pass and be absorbed.
- Add turmeric and a few teaspoons of coconut oil to smoothies, juices, or soup.
- Make a salad dressing from olive oil and turmeric.
For more articles about the different health benefits of turmeric, visit Turmeric.news.
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