The study, published in the journal Science Signaling, revealed that adequate amounts of reactive oxygen species are important signals that trigger the process of repairing muscle cells. According to researchers at the Children's National Health System, mitochondria help repair injured muscle cells or myofibers by absorbing calcium that enters from the area of injury, then using it to promote the production of reactive oxygen species.
Muscle cells need to produce force to make voluntary movements. The force produced by myofibers is transmitted across the muscle, which causes stress that can harm the myofibers. Mitochondria, then, serve as the cell's powerhouse and supply energy for producing force. This process also makes reactive oxygen species as a by-product. Mitochondria need to produce oxidative signals in response to muscle damage in order to help injured muscles repair. These oxidative signals are balanced by the antioxidant defenses in healthy cells. This emphasizes the importance of properly functioning mitochondria both for energy production and repair of injured muscle cells.
Loading up mitochondria with too many antioxidants prevents this signaling process, hindering muscle repair, worsening myofiber damage, and reducing muscle strength. However, an imbalance in the oxidative signals can be harmful as well. The oxidant-antioxidant balance can be interrupted in diseases such as Duchenne muscular dystrophy. This disease is due to a lack of the muscle-specific protein called dystrophin. A dystrophin deficiency makes the muscle cell plasma membrane more prone to injury.
Based on an experimental model of Duchenne muscular dystrophy, the muscles appear normal at birth, but within weeks, muscle damage and progressive weakness become evident. During the third and fourth week, mitochondrial functionality changes. Mitochondria end up being dysfunctional, impairing the repair of injured muscle cells. Furthermore, this enables chronic and excessive oxidation of the myofibers and proper oxidant-antioxidant balance to be disrupted. In this case, antioxidant supplements may bring back balance and help reverse muscle damage and progressive weakness.
"Our results suggest a physiological role for mitochondria in plasma membrane repair in injured muscle cells, a role that highlights a beneficial effect of reactive oxygen species," said Jyoti K. Jaiswal, senior author of the study.
The researchers concluded that the reactive oxygen species and antioxidants in the body need to be balanced in order to actually be helpful in repairing muscles.
After a workout, the muscles become sore. To ease the pain and speed up recovery, eat the right recovery foods, such as:
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