In a study published in the journal BMC Complementary and Alternative Medicine, South Korean researchers showed that DML can mitigate the brain damage caused by mercury poisoning. DML can also reverse the decrease in proliferating cells and differentiated neuroblasts induced by mercury.
Dendropanax morbifera, a natural memory booster
Researchers from South Korea investigated the effects of DML and galantamine on the cognitive abilities of dimethylmercury (MeHg)-treated rats. Galantamine is an oral drug used to treat cognitive decline in patients with mild to moderate Alzheimer's disease.
For their experiment, the researchers randomly divided seven-week-old rats into four groups:
- Distilled water and saline-treated control group
- Distilled water and MeHg-treated group
- MeHg and DML-treated group
- MeHg and galantamine-treated group
The researchers administered galantamine and DML to the animals every day for 36 days.
On the 34th day, they subjected the rats to a novel object recognition test one hour after treatment. The researchers allowed the rats to first explore two identical objects placed at opposite ends of an apparatus. After an hour, they replaced one of the objects with a new one. The researchers used this test to measure the rats' ability to discriminate between different objects.
The researchers also used the Morris water maze test to measure the rats' learning and memory ability. For this test, they placed the animals in a water maze pool divided into four quadrants. They randomly trained each rat in every quadrant and measure how long each would take to find the escape platform.
The researchers reported that MeHg-treated rats took longer than the control group to find the escape platform in the water maze test. They also spent more time exploring during the novel object recognition test. These results suggested that the MeHg-treated rats had problems with spatial memory and learning. (Related: Improve memory loss by using natural alternatives.)
On the other hand, treatment with either galantamine or DML enhanced cognitive function in the MeHg-exposed rats. This was evidenced by how DML- or galantamine-treated rats spent significantly less time looking for the escape platform and familiarizing themselves with a new object than untreated rats.
The researchers also found that DML inhibited the negative effects of MeHg on proliferating cells and differentiated neuroblasts. They noted that the positive benefits of DML were comparable to galantamine. Both treatments also reduced the activity of acetylcholinesterase (AChE), an enzyme involved in the breakdown of acetylcholine. Acetylcholine is a neurotransmitter involved in learning and memory.
"This result is consistent with that of a previous study demonstrating that administration of an ethyl acetate fraction from Dendropanax morbifera lowered AChE activity compared with that in the high-fat diet fed group," the researchers wrote.
The researchers concluded that the positive effects of DML on cognition could make it useful as a memory-boosting functional food that can also mitigate the damage caused by mercury poisoning.
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Sources include:
BMCComplementAlternMed.BioMedCentral.com
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