The potential neuroprotective properties of salidroside from Rhodiola rosea
06/24/2019 // Janine Acero // Views

Researchers from China investigated the potential neuroprotective properties of salidroside, a chemical compound found in the plant Rhodiola rosea. Their findings were published in The American Journal of Chinese Medicine.

  • Microglial activation leads to increased production of pro-inflammatory enzymes and cytokines, which is considered to be a key factor in neurodegenerative diseases. Only a few drugs target microglial activation.
  • Recent studies have indicated that the chemical compound salidroside (Sal), which is used in traditional Chinese medicine, shows anti-inflammatory effects.
  • The current study aims to explore the effect of Sal on microglia activation in lipopolysaccharide (LPS)-stimulated BV-2 cells.
  • The researchers found that Sal significantly inhibits the excessive production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated BV2 cells.
  • They also found that Sal treatment could suppress the mRNA and protein expressions of inflammatory enzymes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
  • The researchers posited that these mechanisms may be related to the inhibition of the activation of nuclear factor-kappa B (NF-kB) and endoplasmic reticulum stress.
  • The results showed that salidroside could inhibit lipopolysaccharide-induced microglia activation via the inhibition of the NF-kB pathway and endoplasmic reticulum stress.

Based on their findings, the researchers concluded that salidroside could be a promising therapeutic agent for human neurodegenerative diseases.

Journal Reference:

Wang C, Lou Y, Xu J, Feng Z, Chen Y, Tang Q, Wang Q, Jin H, Wu Y, Tian N, Zhou Y, Xu H, Zhang X. ENDOPLASMIC RETICULUM STRESS AND NF-KB PATHWAY IN SALIDROSIDE MEDIATED NEUROPROTECTION: POTENTIAL OF NEURODEGENERATIVE DISEASES. The American Journal of Chinese Medicine. 2017;45(07):1459–1475. DOI: 10.1142/s0192415x17500793

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.