Danggui is a commonly used herb in traditional Chinese medicine. Its medicinal applications include replenishing blood and treating menstrual disorders. Previous studies on Danggui led to the isolation and identification of a bioactive compound, now identified as N-butylidenephthalide, which has antiproliferative and cytotoxic effects on cancer cells. This discovery caused researchers to believe that Danggui can be used as a potential treatment for cancer.
For this study, the researchers first evaluated the effects of Danggui exposure on bladder cancer based on data found in Taiwan’s National Health Insurance Research Database. From the information that they had on 17,091 patients, they observed that only eight patients exposed to Danggui developed bladder cancer. Meanwhile, 22 patients that had no Danggui exposure got bladder cancer. This proves that Danggui has anticancer potential, which could be attributed to the presence of N-butylidenephthalide.
The researchers determined if N-butylidenephthalide is responsible for reducing bladder cancer risk by conducting in vitro and in vivo experiments. In vitro studies were done using bladder cancer cell culture. It was observed that N-butylidenephthalide treatment caused the cells to undergo mitochondria-mediated apoptosis, as indicated by the activation of caspase 9 and 3. Additionally, the researchers observed that N-butylidenephthalide prevented cells from migrating and invading other areas.
For the in vivo evaluation of N-butylidenephthalide's anticancer activity, the researchers transplanted bladder cancer cells to mice. They observed that treatment with N-butylidenephthalide inhibited proliferation of the cells while promoting apoptosis.
Overall, these results show that Danggui has anticancer properties that can be attributed to the presence of N-butylidenephthalide. This bioactive compound was shown to have antiproliferative and anti-metastatic activity in bladder cancer cells. For better anticancer activity, Danggui can also be used with known anticancer foods. (Related: Raw broccoli, cabbage slash bladder cancer risk by 40 percent; cooking destroys benefits.)
To avoid having to worry about bladder cancer treatment, it is important to avoid factors that may increase the risk of developing it. Some risk factors of bladder cancer include:
Learn more about other traditional Chinese medicines that have anti-cancer properties by visiting ChineseMedicine.news today.