Cucumbers suppress inflammation in vascular endothelial cells
09/06/2018 // Edsel Cook // Views

An Italian study investigated the anti-inflammatory properties of cucumber (Cucumis sativus) on vascular endothelial cells that line the inner side of blood vessels. It concluded that cucumber-derived extracts could protect the endothelium's vulnerable cells against the inflammation caused by lipopolysaccharides.

The study was supported by the University of Bologna. Its findings were published in the journal BMC Complementary and Alternative Medicine.

  • Researchers prepared cultures of aortic endothelial cells drawn from pigs, which are used as a substitute for human endothelial cells. These cells were exposed to pro-inflammatory lipopolysaccharides and increasing doses of cucumber-based water/ethanol extract.
  • The treated cultures were evaluated for cell viability, the gene expression of endothelial cell markers, the amount of cytokines released by the cells, and the in vitro formation of new blood vessels from existing ones (angiogenesis).
  • The cucumber extract was shown to reduce the toxic effect of lipopolysaccharides on endothelial cells. It also reduced cellular detachment from the endothelium and improved the expression of the protein tight junction zona occludens-1.
  • The extract increased the activity of Hemeoxygenase (HO)-1, a protective gene that counters the effect of the lipopolysaccharide-activated TLR4 gene. It also prevented the early and late secretion of several inflammation-causing chemicals.
  • Furthermore, all doses (0.02, 0.2, and 2 milligrams/milliliter) of the cucumber extract are able to mitigate the release of anti-inflammatories and prevented angiogenesis caused by lipopolysaccharides.

The researchers concluded that cucumber can attenuate the inflammatory effects of lipopolysaccharides in the endothelial cells of pigs, making it a potential means of naturally protecting the vascular endothelium.

The full study can be viewed at this link. You can find other articles about healing plants at

Journal reference

Bernardini C, Zannoni A, Bertocchi M, Tubon I, Fernandez M, Forni M. WATER/ETHANOL EXTRACT OF CUCUMIS SATIVUS L. FRUIT ATTENUATES LIPOPOLYSACCHARIDE-INDUCED INFLAMMATORY RESPONSE IN ENDOTHELIAL CELLS. BMC Complementary and Alternative Medicine. 25 June 2018;18(194). DOI: 10.1186/s12906-018-2254-1.

Take Action:
Support Natural News by linking to this article from your website.
Permalink to this article:
Embed article link:
Reprinting this article:
Non-commercial use is permitted with credit to (including a clickable link).
Please contact us for more information.
Free Email Alerts
Get independent news alerts on natural cures, food lab tests, cannabis medicine, science, robotics, drones, privacy and more.
App Store
Android App
eTrust Pro Certified

This site is part of the Natural News Network © 2022 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

This site uses cookies
Natural News uses cookies to improve your experience on our site. By using this site, you agree to our privacy policy.
Learn More
Get 100% real, uncensored news delivered straight to your inbox
You can unsubscribe at any time. Your email privacy is completely protected.