JPYSF is a Chinese herbal decoction that has long been used for treating chronic kidney disease. It is used to fortify the spleen and tonify the kidney, as well as to activate blood and resolve stasis. However, the mechanisms for these effects remains unclear.
The Chinese researchers aimed to evaluate the therapeutic effects and possible mechanisms of JPYSF on retarding the progression of chronic kidney disease in 5/6 nephrectomized (5/6 Nx) rats. They administered perindopril (4?mg/kg/d) and JPYSF (2.72?g/kg/d) to 5/6 Nx rats by gavage every day for six?weeks.
They evaluated the therapeutic effects of JPYSF by renal function, pathological injury, and fibrosis. They also measured the protein levels associated with mitochondrial quality control network using Western blot and immunofluorescence analysis.
The 5/6 Nx rats exhibited a significant decline in renal function as evidenced by increased serum creatinine, blood urea nitrogen, and urinary protein excretion. There was also significant injury in kidney structure as evidenced by glomerular hypertrophy, tubular atrophy, and interstitial fibrosis.
The kidneys of 5/6 Nx rats showed unbalanced mitochondrial quality control network manifested as decreased mitochondrial biogenesis, fusion, and mitophagy, and increased mitochondrial fission.
JPYSF-treated rats showed improvements in both renal function and kidney structure. JPYSF treatment also showed potential in restoring aspects of the mitochondrial quality control network.
Based on these results, the researchers concluded that treatment with JPYSF can ameliorate 5/6 Nx-induced chronic kidney disease, which may be related to the modulation of the mitochondrial quality control network. (Related: Jian-Pi-Yi-Shen, a Chinese herbal decoction, found to promote kidney health.)
Kidney diseases are usually the result of preexisting conditions such as diabetes, high blood pressure, heart disease, and a family history of kidney failure. It is estimated that 30 million people in the U.S. have chronic kidney disease. The term “chronic kidney disease” means lasting damage to the kidneys that can get worse over time and lead to kidney failure.
Preventing the onset of other diseases may help reduce your risk of developing kidney disease. Here are some tips for keeping your kidneys healthy and functioning properly. (h/t to WorldKidneyDay.org)
Visit Prevention.news for more tips on how to prevent kidney disease and other health problems.