Diabetes mellitus patients can have either Type 1 or Type 2 diabetes. Type 1 is characterized by reduced production of insulin due to damaged pancreatic cells. Meanwhile, Type 2 is caused by increased resistance to insulin function. Although there are many medications for diabetes, many of these exhibit adverse side effects, which is why naturally occurring antidiabetic agents are preferred.
The loop-rot mangrove is a commonly used ethnomedicinal plant in India. Previous studies have shown that this plant exhibits hypoglycemic, antioxidant, anti-cancer, anti-nociceptive, antiplasmodial, and anti-HIV properties. These properties can be attributed to the presence of various phytochemicals, such as alkaloids, flavonoids, and terpenoids.
In this study, which was published in Herbal Medicine: Open Access, the researchers analyzed the phytochemical content of extracts from loop-rot mangrove leaves. It was observed that the extracts contain phenolics, saponin terpenoids, and flavonoids, just as previous studies have said.
The researchers conducted in vivo analysis of the effects of loop-rot mangrove extracts on male albino Wistar rats induced with Type 1 and Type 2 diabetes. They initially determined if the extracts exhibit toxicity against the rats. Fortunately, results showed that the extracts were safe and do not pose harmful side effects up to a concentration of 2000mg/kg. The extent of the antidiabetic effect of the extracts was determined based on the serum's sugar, total cholesterol, triglyceride, and lipoprotein cholesterol levels. It was observed that blood sugar levels of diabetic rats treated with the extracts were maximally reduced by 20 percent after two hours. Additionally, the extracts did not reduce glucose levels in a dose-dependent manner. The researchers also observed a significant reduction in the animals' level of the bad cholesterol or low-density lipoprotein.
Overall, the results of the study show that leaf extracts from loop-rot mangrove can be used for treating diabetes since it possesses antihyperlipidemic and hypoglycemic activities. These activities are brought about by the presence of phytochemicals, which can be further characterized in future studies. From these results, it can be determined that loop-rot mangrove extracts can serve as safe and effective alternatives for existing diabetes medications that have harmful side effects. (Related: Pfizer lawsuits mount due to Lipitor side effects.)
Aside from loop-rot mangrove, the following herbs also have potential uses in diabetes treatment:
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