In this study, published in the journal Frontiers in Molecular Biosciences, the researchers reviewed existing research regarding migraine sensitivity, nerve reactions to migraine triggers, and sex hormones to establish a connection between them. Initially, it was believed that sex hormones induced migraines by regulating the immune system, which could lead to inflammation and a consequent increase in the sensitivity of pain receptors. However, this study revealed that hormones are directly involved in pain receptor signaling.
Sex hormones were observed to modulate neurons in the cranial nerve that are part of the trigeminovascular system, which is involved in migraine pathology. Testosterone, which is produced by males, had a protective effect on the nerves making them less susceptible to migraines. On the other hand, prolactin and estrogen were shown to increase sensitivity to pain, so women suffer from higher migraine incidence because they produce more of these.
"Although this is a complex process, we believe that modulation of the trigeminovascular system by sex hormones plays an important role that has not been properly addressed," said Professor Antonio Ferrer-Montiel from The Miguel Hernández University of Elche who is also the lead author of the study.
With a better understanding of migraine pathology, it is now possible to find more appropriate treatments that can address factors that weren't considered before. This is important to prevent complications due to this condition. (Related: Migraines may permanently damage your brain structure: Here is a natural, research-proven way to treat them.)
Conventional medications for migraines, such as aspirin, ibuprofen, and acetaminophen, are widely used. However, these drugs have side effects like weight gain, dizziness, nausea, low blood pressure, and drowsiness. To alleviate migraines without having to worry about side effects, you can give the following home remedies a try.
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