Lipid-soluble vitamins – which includes vitamins A, D, E, and K – are those that dissolve in organic solvents. Other vitamins such as vitamin C and the B vitamins dissolve in water. These vitamins are also referred to as fat-soluble vitamins since these are stored in the body.
All vitamins help the body – if they are taken in small amounts. Fat-soluble vitamins, for instance, are not lost in the cooking process, allowing the body to absorb them for use. However, the body does not need to consume more than the recommended daily intake (RDI) which is already covered by consuming a balanced diet. The danger lies when people consume massive amounts of fat-soluble vitamins. In megadoses, these can be toxic and result in health problems. These may also interfere with vitamin absorption, leading to nutrient deficiency.
In the study, Csaba classified lipid-soluble vitamins as "exohormones," compounds that can be bound and influence hormone receptors. In the paper, he explained further: "Vitamin D is a transition between endo- and exohormones and the possibility of [a] similar situation in case of other lipid-soluble hormones is discussed."
This is especially risky in newborn children, as exposing them to synthetic fat-soluble vitamins can cause faulty perinatal hormonal imprinting, a condition similar to that found in synthetic endohormones. This can lead to lifelong complications marked by altered sexuality, changes in brain function and development, immunity, and bone development, as well as a higher risk of getting fractures. Hormonal imprinting, being the epigenetic process that it is, is not limited to one lifetime: The consequences of one-time exposure to fat-soluble vitamins are passed on from one generation to the next. The effect, however, varies from one vitamin to the next because hormones differ in the way they react to these vitamins. (Related: The deadly effects of synthetic vitamin K.)
Based on the results, Csaba calls for further studies to better understand the negative outcomes of faulty perinatal vitamin-caused hormonal imprinting.
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