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Natural compounds to modulate estrogen metabolism

The hydroxylation process takes place on three major estrogen molecules. These include 2-hydroxyestrone (2-OH), 4-hydroxyestrone (4-OH) and 16-alpha-hydroxyestrone (16-alpha-OH). ... Compounds that help reduce the 4-OH and 16-alpha OH subtypes and increase 2-OH are desired for good estrogen metabolism. "...

Got man boobs? It's not the soy, it's the BEER

Wake up and smell the alpha-estrogen. So, what are the REAL estrogenic effects of soy, and why is that the popular narrative – that soy causes man boobs? ... Turns out, the phytoestrogens in beer attach to the alpha-estrogen receptors (as opposed to beta receptors), and that increases risk of breast cancer. "...

Ratio of Good to Bad Estrogens Influences Your Breast Cancer Risk

While women have many different estrogens in their body, the estrogen compounds called 2-hydroxyestrone and 16-alpha-hydroxyestrone are by far the most important for breast health. 2-hydroxyestrone is considered 'The Good Estrogen' because its presence doesn't seem to increase breast cancer risks, and MAY even be protective against it. However, 16-alpha-hydroxyestrone is considered 'The Bad Estrogen' because its presence seems to INCREASE breast cancer ...

DIM Lowers Potential of Cancer Cell Metastasis, Invasion and Angiogenesis

Estrogen is a growth promoting hormone in men as well as in women. DIM promotes the same beneficial estrogen metabolism in men that it does in women. ... In dividing cells, the growth promoting signal from estrogen is limited by the reduction of the activity level of the estrogen receptor system. "...

Supplements of DIM Stop Many Cancers in Their Tracks

Improper metabolism of estrogen allows for oxidation and damage to DNA. It also spurs the growth of estrogen sensitive cancers. ... DIM balances the natural response to estrogen by adjusting the activity of metabolic enzymes and specialized estrogen receptor molecules. "...

Breast Cancer Discovery: Vitamin A Derivative Normalizes Cell Growth

The results showed that 39 percent of the genomic regions bound by the estrogen receptor known as alpha overlapped with the estrogen receptors bound by retinoic acid. ... Some of the genes that are expressed in malignant breast tumors don't have estrogen receptors so anti-estrogen drugs can't be used as therapies. "...

Breast Cancer Discovery: Vitamin A Derivative Normalizes Cell Growth

The results showed that 39 percent of the genomic regions bound by the estrogen receptor known as alpha overlapped with the estrogen receptors bound by retinoic acid. ... Some of the genes that are expressed in malignant breast tumors don't have estrogen receptors so anti-estrogen drugs can't be used as therapies. "...

Food for thought: compound in licorice may protect brain cells from Alzheimer's and other diseases

LQ is one of several natural phytoestrogens which mimics the hormone estrogen. There are two forms of phytoestrogens that bind to either alpha or beta estrogen receptors (ER) in the human body. ... "Alpha and beta estrogen receptors are very close in structure, but beta estrogen receptors are more localized in the brain and have different effects on brain cells," Dr. "...

Study looks at the anticancer potential of melatonin

It primarily targets hypoxia-induced factor-1alpha (HIF-1alpha) and the genes under its control, such as vascular endothelial growth factor (VEGF). ... It wards off harmful xenoestrogens and inhibits estrogen production in breast adipose fibroblasts (BAFs) to prevent estrogen overdose. "...

New Understanding of the Role of Testosterone in Women

Progesterone did not alter estradiol's proliferative effects, but testosterone reduced estradiol proliferation by approximately 40%, and entirely abolished estradiol induced augmentation of estrogen receptor alpha expression. ... Researchers concluded that androgen induced down-regulation of mammary epithelial proliferation and estrogen receptor expression suggests that combined estrogen/androgen hormone replacement may reduce the risk of breast cancer associated ...

Seven ways to naturally boost DHT levels for maximum testosterone health

Unlike other forms of testosterone, DHT can't be converted by the aromatase enzyme 5-alpha-reductase into estrogen. ... As explained by Anabolic Men, belly fat causes estrogen levels to skyrocket because it increases levels of not only 5-alpha-reductase, which destroys other forms of testosterone, but also cortisol, a stress hormone that causes decreases in testosterone. "...

Natural Aromatase Inhibitors are Best Prevention of Breast Cancer in Postmenopausal Women

Estrogen receptors (ER) alpha and beta are proteins found inside certain healthy cells of breast tissue. ... In stimulation assays they found that anti-estrogen drugs such as tamoxifen increased ER alpha expression and left ER beta unchanged. "...

DIM Lowers Potential of Cancer Cell Metastasis, Invasion and Angiogenesis

Estrogen is a growth promoting hormone in men as well as in women. DIM promotes the same beneficial estrogen metabolism in men that it does in women. ... In dividing cells, the growth promoting signal from estrogen is limited by the reduction of the activity level of the estrogen receptor system. "...

Groundbreaking Study has Major Implications for Health of Women

Estrogen receptors are activated by the hormone17-beta estradiol, the most aggressive form of estrogen. ... She notes that testosterone has been shown to prevent proliferation, decrease estrogen receptor alpha to reduce estrogen activity, and prevent the stimulation of breast tissue. "...

Supplements of DIM Stop Many Cancers in Their Tracks

Improper metabolism of estrogen allows for oxidation and damage to DNA. It also spurs the growth of estrogen sensitive cancers. ... DIM balances the natural response to estrogen by adjusting the activity of metabolic enzymes and specialized estrogen receptor molecules. "...

Prostate problems and poor testosterone metabolism and aromatization

The biggest factor involved with prostatic health is the androgen to estrogen ratio. In particular, this means the ratio between testosterone/DHT and estrogen molecules. "...

The glossy privet fruit, a popular Chinese herbal medicine, can prevent osteoporosis in menopausal women

The hormone does this through estrogen receptor alpha (ERα) and estrogen receptor beta (Erβ). Estrogen levels drop during menopause. The study was conducted by a group of scientists at Beijing University of Chinese Medicine in China who looked at the effects of the glossy privet fruit on estrogen receptors in the femurs, tibias, and uteri, and uterus weight in ovariectomized mice. "...

Tocotrienol replaces tocopherol as the new face of vitamin E

Alpha-tocopherol is the first vitamin E analog to be recognized, but eight chemically distinct analogs are now known: four (alpha-, beta-, delta- and gamma) tocopherols (TP) and four (alpha-, beta-, delta- and gamma) tocotrienols (T3). ... Some studies even suggest that alpha-tocopherol interferes with the helpful activity of tocotrienols . "...

New Understanding of the Role of Testosterone in Women

Progesterone did not alter estradiol's proliferative effects, but testosterone reduced estradiol proliferation by approximately 40%, and entirely abolished estradiol induced augmentation of estrogen receptor alpha expression. ... Researchers concluded that androgen induced down-regulation of mammary epithelial proliferation and estrogen receptor expression suggests that combined estrogen/androgen hormone replacement may reduce the risk of breast cancer associated ...

Scientists look at the role of antioxidants in lessening the occurrence of Type 1 diabetes in young women

“It actually causes blood vessel constriction when you have high levels of estrogen.” ... Sirt1 levels naturally increase in the high-estrogen days of the cycle, but having diabetes reduces that increase. "...