. - They observed that administration of V. mandshurica to the mice reduced the following: - Body weight - Liver weight - Serum levels of lipids, such as total cholesterol, low-density lipoprotein-cholesterol, and triglycerides - Glucose - Alaninetransaminase (ALT) - Aspartate transaminase (AST) - Histopathologic analyses of the aorta and liver of mice revealed that V. mandshurica attenuated atherosclerotic lesions and reduced lipid accumulation, inflammatory responses, ...
. - They found that alanine aminotransferase (ALT) and aspartate transaminase (AST) activity, deposition of collagen, hydroxyproline content, and expression of alpha-smooth muscle actin (alpha-SMA) and collagen type I (Col I) significantly decreased after treatment with GPs. - Treatment with 5M CCl4 significantly increased the expression of HPC markers, Sox9 and cytokeratin 19 (CK19). - Immunostaining showed that the number of Sox9 and alpha-SMA double-positive cells was higher ...
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