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A compound in brown seaweed helps manage symptoms of diabetes – study

March 03, 2020 - adipocytes (fat cells) and exert anti-diabetic effects. To test this hypothesis, they isolated fucoidan from wakame and treated adipocytes with 10, 50, 100 and 200 micrograms per milliliter (mcg/mL) of fucoidan. Then, they assessed lipid accumulation during adipocyte differentiation.

The researchers reported that fucoidan reduced lipid accumulation and glycerol-3-phosphate dehydrogenase (GDPH) activity -- both of which are dysregulated in diabetes -- in a ...

Investigating the anti-diabetic effects of fucoidan

February 11, 2020 -

Based on these results, the researchers concluded that fucoidan exerts its anti-diabetic effects by improving insulin-stimulated glucose uptake and inhibiting basal lipolysis in adipocytes without inducing adipogenesis.

Journal Reference:

Sim SY, Shin YE, Kim HK. FUCOIDAN FROM UNDARIA PINNATIFIDA HAS ANTI-DIABETIC EFFECTS BY STIMULATION OF GLUCOSE UPTAKE AND REDUCTION OF BASAL LIPOLYSIS IN 3T3-L1 ADIPOCYTES....

Researchers develop method to eliminate scarring by getting wounds to heal as normal skin instead of scar tissue

February 27, 2018 - adipocytes, which is basically the same as the skin you were born with. This means that freshly healed wounds with this type of tissue will eventually blend with your healthy skin tissue, making it looks as if you were never wounded in the first place.

Meanwhile, scar tissue is said to be made up almost entirely of a different kind of cell: myofibroblasts. Scar tissue doesn't contain any fat cells at all, and instead of blending with your normal skin tissue, ...

Coffee bean extracts contain anti-inflammatory compounds that can help fight chronic disease

August 10, 2021 - adipocytes (fat cells) and their mechanism of action hadn't been detailed before.

The team tested the effect of five pure phenolics found in coffee husk and silverskin on adipocytes and immune response cells called macrophages. These two types of cells work together in a loop in obesity-related inflammation, which increases oxidative stress and interferes with glucose uptake.

"Macrophages are present in the adipose tissue and when adipose tissue ...

A traditional Malaysian medicine can help diabetics manage their blood sugar levels

September 07, 2018 - adipocytes. After the test, researchers investigated the cells in vitro and examined its anti-diabetes properties using insulin-like and insulin-sensitizing actions. These were also compared to rosiglitazone, a drug typically used in diabetes treatments. Plant derivatives were also tested to determine the safest concentrations of each, and subfractions were isolated further and tested for its physicochemical components.

From the tests, researchers identified four ...

Study: Cinnamon compound boosts metabolic health and helps fight obesity

June 14, 2022 - adipocytes (fat cells), making them start burning energy via a process called thermogenesis.

The researchers tested human adipocytes from participants representing a range of ages, ethnicities and body mass indices. After treating the cells with cinnamaldehyde, the researchers observed the increased expression of several genes and enzymes that boost lipid metabolism.

Wu and her team also observed an increase in Ucp1 and Fgf21, which are important metabolic ...

This overlooked member of the citrus family has antioxidant, antidiabetes, and anticancer properties

May 22, 2019 - adipocytes and HepG2 hepatocarcinoma cells. 3t3-L1 adipocytes are fat cells derived from mice, while HepG2 is a human liver cancer cell line. Using ferric reducing antioxidant power (FRAP) assay, they found that the 60 percent ethanolic ML extract had high antioxidant activity. That same extract also contained phenolic compounds and flavonoids.

To determine if the ML extract has antidiabetic potential, they used 2-NBDG, a fluorescent indicator, to measure glucose ...

Studies show that ordinary household dust may be the reason why you’re fat and sick

October 16, 2018 - adipocytes, which function as precursors for fat cells. Researchers at Duke University tested 11 different house dust samples and found that seven of them caused adipocytes to grow and turn into fat, while nine of them caused adipocytes to both increase in number and proliferate.

These same researchers identified the flame retardant TBPDP, the plasticizer DBP, and the pesticide pyraclostrobin as having the greatest and worst impacts on fat accumulation....

A traditional plant native to Thailand effectively manages obesity, according to new study

August 15, 2018 -

For the study, researchers from Suranaree University of Technology in Thailand derived the extract of broken bones from the fruit pods of the plant. They looked at the effects of broken bones plant extract on the adipogenic and biomolecular change in 3T3-L1 adipocytes. They used the cell line 3T3-L1 to establish the potential toxic effects of broken bones plant extract during adipogenesis, the differentiation of pre-adipocytes into adipocytes.

In ...

Purple corn is an ancient superfood that can fight diabetes and obesity

September 27, 2019 - adipocytes with large immune cells called macrophages to simulate the cells of obese people with high concentrations of lipids and inflammation. They also examined models that simulated the cells of healthy people who regularly consumed plant-based foods rich in polyphenols.

Focusing on specific biomarkers related to inflammation and adipogenesis, the researchers observed that the phenols in the extracts altered the development of adipocytes, reducing ...

Caulerpa okamurae can potentially treat obesity and metabolic disorders

April 18, 2019 -

The researchers concluded that C. okamurae has potential anti-obesity properties and can be used in therapies for the condition.

Journal Reference:

Sharma BR, Kim HJ, Kim MS, Park CM, Rhyu DY. CAULERPA OKAMURAE EXTRACT INHIBITS ADIPOGENESIS IN 3T3-L1 ADIPOCYTES AND PREVENTS HIGH-FAT DIET-INDUCED OBESITY IN C57BL/6 MICE. Nutrition Research. November 2017;47:44–52. DOI: 10.1016/j.nutres.2017.09.002

This ...

Stem juice from bananas a potential natural cure for diabetes

October 18, 2018 - adipocytes. Researchers observed that stem juice from both sources had the same level of inhibition for alpha-glucosidase. This inhibitory activity was also shown to follow a dose-dependent manner. Meanwhile, there was no significant inhibition of alpha-amylase for both samples, although stem juice from the bananas grown in Vietnam did have a slightly higher level of inhibition. Lastly, the researchers also saw that neither of the samples was able to prevent cells from ...

Fermented green tea can control adiposity and lipid metabolism, effectively ameliorating obesity

September 02, 2020 -

Based on these findings, the researchers concluded that FGT is a novel functional food that can be used to control adiposity and lipid metabolism.

Journal Reference:

Cho D, Jeong HW, Kim JK, Kim AY, Hong YD, Lee J-H, Choi JK, Seo DB. GALLOCATECHIN GALLATE-CONTAINING FERMENTED GREEN TEA EXTRACT AMELIORATES OBESITY AND HYPERTRIGLYCERIDEMIA THROUGH THE MODULATION OF LIPID METABOLISM IN ADIPOCYTES AND MYOCYTES....

Fermented green tea is a novel functional food that can help reduce obesity and regulate triglyceride levels

October 01, 2020 - adipocytes (fat cells) with an extract derived from it. They found that the fermented green tree extract (FGT) inhibited adipogenesis and lipogenesis in adipocytes and also augmented the mRNA expression of fatty acid oxidation-related genes in differentiated myocytes (muscle cells). Fatty acid oxidation is the process by which fatty acids are broken down in the mitochondria to produce energy for cells.

Meanwhile, in mice with diet-induced obesity, FGT reduced ...

Cinnamon spice — powdered tree bark — found to accelerate the body’s fat burning

November 23, 2017 -

If you think you’ve heard this before, you’re half right; scientists already knew that the essential oil responsible for cinnamon’s pleasing flavor, cinnamaldehyde, protects mice from obesity and hyperglycemia. However, they weren’t quite sure how it accomplished this and whether it would have the same effect on humans.

In the newest study, researchers from the University of Michigan Life Sciences Unit tested fat cells known as adipocytes from human volunteers ...

Add cinnamon to your treats this holiday season: Research confirms the spice protects against obesity

December 12, 2017 - adipocytes from individuals who represent a range of ages, ethnicities and body mass indices, and treated the adipocytes with cinnamaldehyde. The findings show that cinnamaldehyde enhances metabolic health by responding straight on fat cells which stimulates them to begin burning energy through a process of heat production called thermogenesis. They observed that there was an increased expression of some genes and enzymes that enhance lipid metabolism. In addition, ...

Scientists explore a compound in chestnut flower for its anti-obesity properties

May 15, 2019 - adipocytes. In particular, adipocyte cells are linked to the development and buildup of fat cells in the body. They also looked at the main compounds in the extract responsible for the biological activity.

The researchers found that after the 3T3-L1 cells were exposed to the chestnut flower extracts, these exhibited a reduction in lipid cell build up, especially those in the 3-isobutyl-1-methylxanthine/dexamethasone/insulin (MDI) medium. Phytochemical analysis of the ...

Contaminated HOUSE DUST found to promote growth of body fat

August 21, 2017 - adipocytes to develop into mature fat cells and accumulate triglycerides. Extracts from nine samples spurred the cells to divide, creating a larger pool of precursor fat cells. Only one dust sample had no effect. Additionally, among the 44 individual common house dust contaminants tested in this model, pyraclostrobin (a pesticide), the flame-retardant TBPDP, and DBP, a commonly used plasticizer, had the strongest fat-producing effects.”

The researchers believe that ...

Why Chinese cinnamon should be part of your weight loss plans

May 21, 2019 - adipocytes), two factors that are linked to obesity risk, according to a study in The American Journal of Clinical Nutrition.

"Our results suggest CC [Cinnamomum cassia] extract controls weight gain in obese mice by inhibiting lipid accumulation and increasing energy expenditure, and that its action mechanism involves the up-regulation of mitochondrial biogenesis in skeletal muscle cells," the researchers concluded in their report.

These findings were very similar ...

The anti-obesity effects of ulam raja or “king’s salad,” a plant used in Malaysian cuisine

February 06, 2019 - adipocytes markers. This is what causes the prevention of body weight increase in patients. In short, the use of the plant leaf in the experiment directly lead to a reduced fat gain in their lab experiments, showing the potential for a highly cost-effective way of preventing obesity. And all it takes is just a simple change in one's diet, instead of taking any synthetic medicine. With further tests, these result could likely be further confirmed and reinforced for future ...