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Biologists identify the protein that makes tendon-muscle connections last a lifetime

September 27, 2019 - actin, and talin

During the early stages of development, the cells of an organism are subjected to various mechanical forces that eventually dictate cell fate. To help them sense and resist these forces, cells rely on integrin-based adhesions, which serve as their core force-sensing structures.

Integrins are cell-surface proteins that act as receptors. One of their main functions is to regulate the interaction of individual cells with their microenvironment to ...

Plant cells that enable photosynthesis found to also play a role in plant self defense

July 06, 2018 - actin filaments that comprise the Nicotiniana cell's cytoskeleton.

Given confocal microscopes have relatively low resolutions, transmission electron microscopy (TEM) was used to confirm the stromule-to-microtubule contact.

Next, the researchers used a viral protein to trigger an immune response. The chloroplasts promptly began extending stromules towards the nucleus.

Stromules were shown to follow the length of the microtubules before anchoring themselves ...

Researchers identify betulinic acid as a promising new agent for treating hepatic fibrosis

April 14, 2020 - actin, a marker of fibrosis, and autophagy-related proteins. Autophagy is a cell-regulated process of clearing out unnecessary or damaged cellular components.

The researchers found that betulinic acid can reduce the pathological damage associated with liver fibrosis by decreasing serum platelet-derived growth factor and serum hydroxyproline levels. The former is an important factor that facilitates the progression of liver fibrosis, while the latter is an amino acid ...

Safflower yellow, an herbal medicine used in TCM, found to prevent the spread of breast cancer to the lungs, according to study

October 03, 2019 - actin undergo mutations and are abnormally expressed, they can contribute to the drug resistance and metastatic ability of cancer cells.

Aside from preventing cytoskeletal arrangement, the researchers also found that SY can significantly inhibit the migration of breast cancer cells in vitro and prevent the pulmonary metastasis of breast cancer cells in vivo. EGF stimulation of breast cancer cells (MBA-MD-231) treated with SY resulted in a decrease in the expression ...

Study presents evidence supporting the use of curcumin as alternative treatment for kidney fibrosis

May 07, 2021 - actin (a-SMA) and fibroblast-specific protein 1 (FSP1)) and key proteins involved in the Akt/mammalian target of rapamycin (mTOR) pathway.

The researchers found that low-dose curcumin (3.125 and 25?micromol/L) effectively promoted HKC proliferation. After 72 hours of incubating HKCs with TGF-B1 and curcumin, curcumin caused the cells to maintain epithelial morphology in a dose-dependent manner. It also decreased the expression of EMT-related proteins, such as vimentin, a-SMA and ...

Bupleurum can help treat diabetic kidney injury: Study

October 06, 2020 - actin, which are all proteins involved in the scarring process. Meanwhile, they associated the inhibition of kidney inflammation with reduced levels of tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6), two signaling proteins that help trigger inflammation in response to tissue damage or infections.

BP treatment also suppressed the over-expression of toll-like receptor 4 (TLR4) and high-mobility group box 1 (HMGB1), which are involved in chronic kidney disease, ...

Don’t get injured at night… Researchers discover cell repair driven by circadian rhythm; wounds heal 60% faster during the day

November 11, 2017 - actin, filaments of which provide movement and structure, acting like muscles within the cell.

This study has huge implications for the future of surgery.

O’Neill noted, “In both cells and mice, we can reset the tissue healing response by tricking the cells into thinking it's a different time of day - such as by turning the lights on at night and off at different times of day for the mice, or using body clock-altering drugs on cells in the lab.” ...

Left-wing Austin newspaper now straight-up propaganda rag after REFUSING to run description of black male shooting suspect with dreadlocks

June 15, 2021 - actin' white."

This may be hard for many readers to see and comprehend, but let's face facts: This is all true. Whites, Hispanics, and Asians are not responsible for black culture. Black people are. And only black people can fix it.

Now, back to the Austin American Statesman. Newspaper editors and reporters are not supposed to pick and choose which facts they report. They are supposed to report all facts, and at the time this shooting story was published initially, ...

Poor man’s ginseng found to protect against liver damage

May 30, 2019 - actin (alpha-SMA) and collagen type I (Col I). ALT and AST are markers of liver damage; they are found at high levels in the blood when the liver sustains injuries. Alpha-SMA expression is a marker of hepatic stellate cells activation, which happens in the earliest stages of liver fibrosis. Col I production is increased in cirrhotic livers.

For in vitro analyses, the researchers treated WB-F344 hepatic progenitor cells (HPCs) with transforming growth factor beta 1 (TGF-B1) ...

Prevent liver fibrosis with TCM

October 03, 2018 - actin (alpha-SMA) and collagen type I (collagen I) expression.

The expression levels of tissue inhibitor of metalloproteinases 1 (TIMP1) and TIMP2, which help keep ECM degradation in check, were also decreased after the rats were given CCl4.

The rats given LWWL significantly inhibited CCl4-induced hepatic fibrogenesis. The researchers also observed a decrease in the adhesion of liver tissues, while the texture of the organ was softer and more lustrous. Unlike ...