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Obesity can make breast cancer cells more aggressive

December 21, 2018 -

The study involved a collaboration between researchers from Heidelberg University Hospital, Helmholtz Zentrum München, and Technische Universität München (TUM).Obesity and cytokines

Health experts are worried because the number of people with obesity around the globe is increasing rapidly. The World Health Organization (WHO) reports that the number of obese children and adolescents have increased tenfold from 1975 to 2016.

Extreme obesity is linked to different ...

Being obese can cause breast cancer cells to become more aggressive

October 10, 2018 -

Previous studies have shown that obese individuals are more at risk of cancer. Obesity is a condition where there is an accumulation of body fat and a person's body weight exceeds the ideal weight by at least 20 percent. This causes an expansion of adipose tissue that leads to the release of adipocyte cytokines known as adipokines. These adipokines serve as signals that help the adipose tissue perform its role in regulating cell function, as well as the prevention and spread ...

Obesity and breast cancer: Scientists explain how being overweight makes breast cancer cells more aggressive

August 13, 2018 -

“ACC1 is a key component of fatty acid synthesis,” said Mauricio Berrel Diaz of Helmholtz Zentrum München and one of the leaders of the study. “However, its function is impaired by the cytokines leptin and TGF-?.”

Extremely overweight subjects have been found to have increased levels of cytokines in the blood. The researchers discovered that when ACC1 is inhibited, it results to the accumulation of the fatty acid precursor acetyl-CoA, which is passed ...