In a 2015 study published in the Journal of Dental Research, it was found that as many as 2.4 billion people in the world have cavities. The World Health Organization (WHO) reports that cavities are the most widespread non-communicable disease, which can severely affect the quality of life.
People who have cavities may find it difficult to eat and sleep. If it reaches an advanced stage (abscess), it may even cause a chronic systemic infection.
Cavities can be a serious problem, and the researchers at the University of Washington School of Dentistry looked to the mechanisms behind natural tooth-forming proteins for a possible source of treatment. Their findings led them to a new alternative method that repairs damaged tooth enamel without using a drill.
Researchers studied amelogenin – the protein required to form crown enamel – and came up with amelogenin-derived peptides. Peptides are fundamental components of cells that carry out certain functions, such as potentially repairing tooth enamel.
The newly devised peptides will be used as the active ingredient in the new treatment proposed by the study. “Remineralization guided by peptides is a healthy alternative to current dental health care,” said lead author Mehmet Sarikaya, professor of materials science and engineering and adjunct professor in the Department of Chemical Engineering and Department of Oral Health Sciences at the UW.
“Peptide-enabled formulations will be simple and would be implemented in over-the-counter or clinical products,” said Sarikaya.
The peptides have been tested in the lab and were “proven to bind onto tooth surfaces and recruit calcium and phosphate ions,” according to Deniz Yucesoy, co-author and a doctoral student at the UW.
While still currently in development, the new peptide-based treatment is expected to come in the form of biomimetic toothpaste, gels, solutions, and composites. This will allow the treatment of cavities without the currently practiced dental procedures. (Related: Fight cavities and gingivitis naturally with homemade DIY Oral health.)
It’s possible to prevent cavities altogether, so that you can avoid needing treatments in the first place. Brushing and flossing daily are essential, but to take that a step further, here are some tips to keep cavities at bay:
Being proactive in taking care of your oral health reduces your risk of many dental-related problems. Learn more at HolisticDentistry.news.