Resveratrol and grape seed polyphenols combine to prevent diabetes

Friday, April 29, 2011 by: John Phillip
Tags: resveratrol, diabetes, health news

(NewsTarget) Researchers publishing the results of two independent studies in the British Journal of Nutrition have demonstrated that polyphenol antioxidants found naturally in red grapes can prevent the buildup of fat in muscle tissue that is a precursor to metabolic disorder and diabetes. Resveratrol and grape seed extracts influence how the body responds to insulin, the hormone that controls critical mechanisms of dietary sugar and fat metabolism. The grape-derived compounds have been shown to improve cardiovascular and Alzheimer`s disease risk factors in the past. Information gleaned from these studies explains how daily consumption of the fresh fruit can be invaluable as it prevents muscular fat accumulation leading to metabolic instability and diabetes.

Detailing the result of research performed at the University of Montpellier in France, scientists found that subjects fed a diet high in fat and sugar experienced a lower accumulation of fat in muscle tissue when supplemented with a concentrated extract of red grape polyphenols. Diets high in oxidized saturated fats are known to disrupt the normal function of insulin leading to insulin resistance and diabetes. By limiting the effect of fats on cell membranes, the grape extract was found to provide a significant level of protection against the disease.

In a separate body of research, scientists determined that a 10 mg daily dose of resveratrol was associated with lowered insulin resistance in Type-II diabetics. Resveratrol is a powerful protective anti-fungal compound found in the skin of red grapes. Known to activate a longevity signaling gene (SIRT-1), resveratrol has been shown to extend lifespan by lowering the risks associated with systemic inflammation. The polyphenol may help to prevent cancer development, cardiovascular disease and dementia, and it is now shown to impede the development of diabetes by regulating insulin sensitivity.

Researchers formed two groups of participants and randomly supplemented their diet with resveratrol (5 mg twice a day) or a placebo. After four weeks the resveratrol group showed a significant decrease in insulin sensitivity compared to the placebo group. The study authors explain that the results are likely due to the potent antioxidant action of resveratrol, as oxidative stress is a key contributor to the onset of insulin resistance.

Researchers concluded "The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to more efficient insulin signaling." To maximize the anti-diabetic health benefits of grape polyphenols, health-minded individuals will want to include organically grown red grapes in their diet or supplement with grape seed extract and resveratrol (10 to 25 mg daily).

Article References:
http://www.nutraingredients-usa.com/Research...
http://www.nutraingredients-usa.com/Research...
http://journals.cambridge.org/action/display...

About the author

John Phillip is a Health Researcher and Author who writes regularly on the cutting edge use of diet, lifestyle modifications and targeted supplementation to enhance and improve the quality and length of life. John is the author of 'Your Healthy Weight Loss Plan', a comprehensive EBook explaining how to use Diet, Exercise, Mind and Targeted Supplementation to achieve your weight loss goal. Visit My Optimal Health Resource to continue reading the latest health news updates, and to download your Free 48 page copy of 'Your Healthy Weight Loss Plan'.