Thursday, August 11, 2016 by: Daniel Barker
Tags: bisphenol A, reproductive health, nervous system
The results show that particularly low doses of bisphenol A affect the development of the animals. The female rats that were exposed to the lowest dose weighed more as adults, and their behaviour had changed in a direction that resembled male behaviour. This could indicate masculinization of the females' brains. Male rats that were exposed to the lowest dose had increased growth of mammary gland tissue, and decreased sperm count as adults.
These effects were not observed at the higher bisphenol A doses.
Mammary gland changes that could be indicative of an early stage of breast cancer were observed in aging rats exposed to the second lowest dose of bisphenol A.
The results support previous studies, which show that particularly low doses of bisphenol A can affect the animals' development, while higher doses have different effects.
Endocrine disruptors are the link between human health hazards and plastic. ... In the human body, endocrine disruptors mimic the actions of the hormone estrogen. They upset the hormonal balance and can stimulate the growth of tumors in the breast, uterus or prostate. They can affect fertility, pregnancy, and worse, can affect the fetus by interfering with testosterone, disrupting normal sexual development. This disruption is not often apparent until adulthood and includes the increased risk of cancer.
Pascal Coumailleau of INSERM's Research Institute for Environmental and Occupational Health and the University of Rennes in France and colleagues measured the effects of four bisphenols on the brains of zebrafish.
Exposing the animals to higher concentrations of these chemicals than humans would typically encounter, the team found that three of four BPA analogs—BPS, BPF, and BPAF—are estrogenic, causing an upregulation in the brain of the enzyme aromatase, which converts androgens—such as testosterone—to estrogens. Overall, these chemicals are similar to BPA in their effects....
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