Thursday, April 14, 2016 by: Daniel Barker
Tags: scientific literature, fabricated studies, Big Pharma
The case against science is straightforward: much of the scientific literature, perhaps half, may simply be untrue. Afflicted by studies with small sample sizes, tiny effects, invalid exploratory analyses, and flagrant conflicts of interest, together with an obsession for pursuing fashionable trends of dubious importance, science has taken a turn towards darkness.
It's common for many to dismiss a lot of great work by experts and researchers at various institutions around the globe which isn't "peer-reviewed" and doesn't appear in a "credible" medical journal, but as we can see, "peer-reviewed" doesn't really mean much anymore. "Credible" medical journals continue to lose their tenability in the eyes of experts and employees of the journals themselves, like Dr. Horton.
Clinical trials are also biased through designs for research that are chosen to yield favorable results for sponsors. ... In short, it is often possible to make clinical trials come out pretty much any way you want, which is why it's so important that investigators be truly disinterested in the outcome of their work.
Part of the problem is that no-one is incentivised to be right. ... Instead of changing incentives, perhaps one could remove incentives altogether. Or insist on replicability statements in grant applications and research papers. Or emphasise collaboration, not competition. Or insist on preregistration of protocols. Or reward better pre and post publication peer review. Or improve research training and mentorship.
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