Originally published March 3 2008
DNA and Mitochondrial Time Bombs: Uranium and Mercury
by Mark Sircus Ac., OMD
(NaturalNews) Hyperinsulinemia may promote mammary carcinogenesis. Insulin resistance has been linked to an increased risk of breast cancer and is also characteristic of type 2 diabetes. Diabetes and cancer are both expanding almost exponentially in the world today and can in part be traced to the increasing radiation to which we are all being exposed. Every physician knows that radiation can lead to cancer, but making a connection between radiation and diabetes seems ludicrous at first glance but is anything but. Most medical doctors have never heard of this and neither have they paid attention to the fact that mercury and other toxic chemicals are also primary causes of diabetes. Even though there is little research into the connection between radiation poisoning and diabetes we should not remain blind, deaf and dumb about it.
Diabetes is a fundamental disease that affects the entire colony of cells in a person because it has to do with energy metabolism and the vastly important hormone insulin and its receptor sites.
Thus it comes as no surprise that we find diabetes and cancer intimately linked. About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. This observation has led medical scientists to believe that pancreatic cancer causes the associated diabetes and also that those conditions associated with diabetes promote the development of pancreatic cancer. A study, published by the American Medical Association in 2005, of more than 1 million South Koreans suggests diabetes can raise the risk of developing and dying from several types of cancer, including digestive-tract tumors. We can thus say with reasonable confidence that whatever is causing diabetes is also, in part, causing cancer.
In their book "Infectious Diabetes", Doug Kaufman and Dr. David Holland describe a significant link between diabetes and cancer, pointing out that when our immune system is compromised and unable to fight off a fungal invasion and stop the proliferation, that it is not coincidence that diabetics have a 4 times greater rate of liver cancer. Diabetics also have double the risk of pancreatic cancer compared to non-diabetics according to recent studies presented to the Third Annual Frontiers in Cancer Prevention Research Meeting in Seattle in 2004. Fungi feed on the sugar in the blood stream, as well as in the liver where glycogen is stored for the body's energy needs. The Aspergillus mold toxin, aflatoxin B1, inhibits the breakdown of both glucose, or simple sugar, and glycogen.
The strongest hypothesis to explain why diabetes might increase the risk for certain cancers revolves around hyperinsulinemia, the high blood levels of insulin characteristic of diabetes. "From animal studies we know that high insulin levels can directly promote tumor growth," said Frank Hu, M.D., assistant professor of nutrition at the Harvard University School of Public Health, Boston. Hu and colleagues concluded in a 1999 paper, based on data from the Nurses' Health Study, that diabetes conferred an increased risk of colorectal cancer in women. Patients with diabetes were 1.43 times more likely to get colorectal cancer, and 2.39 times as likely to die of colorectal cancer.
"Depleted (DU) uranium is highly toxic to humans, both chemically as a heavy metal and radiologically as an alpha particle emitter, which is very dangerous when taken internally," writes Dr. Rosalie Bertell, Canadian Epidemiologist. A new study, conducted by biochemist Dr. Diane Stearns at Northern Arizona University confirms that, separate from any radiation risks, cells exposed to uranium will bond with the metal chemically. Uranium and phosphate have a strong chemical affinity for each other and the DNA and Mitochondria are loaded with phosphate so uranium is a DNA and Mitochondria deep penetration bomb. The uranium is attacking on fundamental cellular levels while mercury offers a knock out punch by attacking the sulfur bonds besides being highly toxic to nerve cells.
Diabetes is often conceptualized as a severe imbalance of the part of the endocrine system that destroys our ability to metabolize food. The imbalance results in elevated levels of insulin, a lack of insulin, or the cell insulin receptor sites becoming insensitive to insulin.
Metals such as iron, mercury, arsenic, lead and possibly aluminum play a role in the actual destruction of beta cells through stimulating an auto-immune reaction to them after they have bonded to these cells in the pancreas. It is well documented in the medical literature that chemicals and drugs can cause temporary or permanent insulin-dependent diabetes.
Both mercury and uranium oxide are floating in the environment like invisible clouds that have spread out everywhere. They are raining down on us, damaging and damning our future.
Simultaneous exposure to mercury and uranium shows markedly increased damage to the kidneys than when exposure is to each metal singly. Insulin has three sulfur-containing cross-linkages and the insulin receptor has a tyrosine kinase-containing sulfur bond, which are the preferred targets for binding by both mercury and lead. Should mercury attach to one of these three sulfur bonds it will interfere with the normal biological function of the insulin molecule. Nephrotoxicity of the kidneys with necrosis of proximal tubules has been seen to increase significantly with dual exposure to both uranium and mercury.
In February, 2007 The Canadian Institute for Health Information (CIHI) reported that the number of new cases of kidney failure jumped 114 per cent. The burden of renal disease is also growing rapidly in India. The mean age of End Stage Renal Disease (ESRD) patients requiring dialysis in India is 32-42 years compared to the 60-63 years in the developed world. Chronic kidney disease (CKD) is a worldwide public health problem.
Doctors fear that within a generation or so, a huge wave of new cases could overwhelm the public health system and engulf growing numbers of the young, creating a city where hospitals are swamped by the disease's handiwork, schools scramble for resources as they accommodate diabetic children, and the work force abounds with the blind (New York Times).
We can expect this pandemic in diabetes to contribute directly to rising cancer rates. Lead and aluminum are other common heavy metals that have also been shown to dramatically increase the toxicity of mercury. Interesting also is that lead is the final end product of the step by step radioactive decay of uranium. It would not be far fetched to imagine uranium and lead having very similar chemical characteristics though uranium is twice as dense.
Heavy metals are not the only trigger invoking the acceleration of diabetes. Dr. Lisa Landymore-Lim in her book Poisonous Prescriptions explains clearly how many drugs used by the unsuspecting public today are involved also in the onset of impaired glucose control and diabetes. She explains using the example of the drugs streptozocin, and alloxan, both used in diabetes research to make lab rats diabetic and in Vacor, a rat poison known to cause insulin dependent diabetes in humans. Allopathic medicine has to face up to the fact that many drugs, including most surprisingly, the antibiotics including penicillin, as well as an entire host of others, causes changes in the beta cell and/or insulin function (See Chemical Causes of Diabetes on the IMVA site).
'Thiol poisons, especially mercury and its compounds, reacting with SH groups of proteins lead to the lowered activity of various enzymes containing sulfhydryl groups. This produces a series of disruptions in the functional activity of many organs and tissues of the organism' - Professor I.M. Trakhtenberg, Russia.
It is through mercury's attack on these sulfide bonds (SH) that mercury is able to change the biological properties of proteins and change important physiological functions. What few doctors and health officials recognize is that chemicals and radiation combine to act on the very same cellular enzyme pathways. Lead is no slouch in this area either. The interaction of lead with sulfhydryl (SH) sites causes most of its toxic effects, which include impaired heme synthesis, inhibition of erythrocyte Na/K ATPase, diminished RBC glutathione, shortened RBC life span, impaired synthesis of RNA, DNA and protein and impaired metabolism of vitamin D. Lead may also affect the body's ability to utilize the essential elements calcium, magnesium, and zinc.
One type of contamination reinforces and strengthens the other so medical treatments need to simultaneously address both chemical toxicity and radiation poisoning. Exposure to radiation causes a cascade of free radicals that wreak havoc on the body. Radiation also decimates the body's supply of glutathione, which allows free radicals to run rampant through our tissues and organs. These free radicals are destructive and are one of the most fundamental causes of disease. So we need a broad full spectrum chelator and antioxidant that is certified for both uranium and mercury and a list of other heavy metals and toxins. There are also targeted natural chelation formulas on the market that work well at eliminating uranium in addition to mercury that are not so complete but fit into a total detoxification and chelation program. Importantly, we do not want any medical or healing substance to add its own toxicity to the cesspool of chemicals already present in the body and blood stream.
There are three things that determine the toxicity of radioactive materials:
Chemical effects � Uranium is chemically very toxic.
Radioactive effects (includes half-life and energy released) - One gram of DU (1/20th of a cubic centimeter) releases 13,000 alpha particles a second. One alpha particle can cause cancer under the right conditions and certainly it has the capacity to wreck havoc in beta cells and everywhere else.
Particle size - in the nanoparticle range (diameter of 0.1 microns or smaller) the particulate effect (non-specific catalyst or enzyme) is far more biologically toxic than the first two effects. This is why DU is so devastating (See extensive notes on this in the reference section).
Type Two Diabetes is an increasingly prevalent disease in the world, especially the United States, where the number of new patients grew 49% between 1991 and 2000.
The Chernobyl incident was a major humanitarian disaster, which has resulted in a plethora of health problems that are still far from being fully recognized. Most studies analyzing the medical consequences of this catastrophe have so far focused on diseases such as thyroid cancer, leukemia, immune and autoimmune pathology, even though an increase in the incidence of Type 1 diabetes mellitus, a disorder involving the immune system, was observed within the residential population of Hiroshima among survivors of the atom bomb detonation. Studies have also shown that thymectomy and a sub-lethal dose of gamma radiation induces Type 1 diabetes in rats.
Dr. Chris Busby analyzed bomb crater samples and an air filter from an ambulance used in Beirut in July during the Israeli attack on Lebanon and found not only DU, but also that it was enriched with U235. The US sent the DU bombs to Israel two years ago, which was all over in the US media, and more in July when Israel ran out of them.
Leuren Moret, Livermore Nuclear Weapons Lab whistleblower, predicts that we can expect the use of depleted uranium weaponry by Israel in the recent aggression against Lebanon will continue
to add to increasing diabetes in the region as well as globally.
And behold, alarming news is coming in from northern Israel in the wake of their use of depleted uranium in the recent war in Lebanon. In recent months a sharp increase has been noted in the number of new patients suffering from juvenile diabetes in the north. This is reported by the juvenile diabetes department at Ziv Medical Center, Safed. The staff of this department still has no numerical data on the dramatic increase in the number of new patients, since they continue to arrive at the hospital every day. "The children who have come to us over the past weeks live in Safed and other communities in the Galilee-populations that have not shown such a high incidence of the disease in the past," said Dr. Orna Dali-Gottfried, director of the department of pediatrics, juvenile diabetes and endocrinology at the hospital. The truth seems to indicate that American depleted uranium munitions nuked both Israel and Lebanon.
Researchers at the Paediatric Hospital A. Meyer, Florence, Italy studied this question by assessing the incidence of the disease in children in Gomel, Belarus, in the years subsequent to the Chernobyl disaster. The results of the study seem to confirm the hypothesis of the influence of environmental pollution subsequent to the Chernobyl accident can cause diabetes.
Mass screening for diabetes mellitus has been conducted on 64,000 - 113,000 atomic bomb survivors resident in Hiroshima City since 1961. From 1971 to 1992 a 2.7-fold increase in the prevalence of diabetes mellitus was observed in males and a 3.2-fold increase in females.
Liquidators of the aftermath of the Chernobyl accident (LCA) who had worked within the 30-km zone for not more than 3 months in 1986, and early in the year 1987, were examined in 1988-1992 and again in 1997-1998. Hyperinsulinemia was recordable in these workers with normal and abnormal body mass index for the space of 3 to 12 years after the accident. Hyperinsulinemia, as the researchers saw it, was related to direct or indirect action of irradiation because those persons with prior acute psychogenic stress and healthy people have been found to be free from hyperinsulinemia. The possibility cannot be ruled out that hyperinsulinemia is a predictor of increased body weight gain and obesity in these workers.
We have a significant and documented increase in the incidence of Type 1 diabetes in children and
adolescents after Chernobyl in the radioactively contaminated area of Gomel compared to Minsk (Heinrich Heine, University Dusseldorf, Germany).
Dr Chris Busby, who has extensively researched the low-level radiation threat, and is the scientist who revealed vastly increased radiation levels over England after the last attack on Iraq, has made a link between everyday radiation exposure and a range of modern ailments: "There have been tremendous increases in diseases resulting from the breakdown of the immune system in the last 20 years: diabetes, asthma, AIDS and others which may have an immune-system link, such as MS and ME. A whole spectrum of neurological conditions of unknown origin has developed."
According to Moret, it won't take more than two days for the uranium particles to reach India from Iran. Egypt, the Middle East, Central Asia and Pakistan would also be affected.
Scientists may be seriously wrong in their idea of just how much increased background radiation the human body can withstand without long term effects. Public health officials across the board tend to grossly underestimate the dangers and medical officials are out there claiming, as usual, that toxic substances are actually good for your children. They say that about mercury and they say that about radiation.
Along with the pancreas, insulin receptor sites are vulnerable to chemical poisoning like any other part of the body. Perhaps these aspects of human physiology are even more sensitive and that is why we are seeing exploding rates of diabetes.
Dr. Herman Muller, who has received a Nobel Prize for his work, has shown how the human race's continuous exposure to so-called 'low-level' radiation is causing a gradual reduction in its ability to survive, as successive generations are genetically damaged. "The spreading and accumulation of even tiny genetic mutations pass through family lines, provoking allergies, asthma, juvenile diabetes, hypertension, arthritis, high blood cholesterol conditions, and muscular and bone defects." A Los Angeles Times front-page report on 16 September 2006 claims that there are more than 41 million Americans with blood glucose abnormalities "that indicate they may soon develop diabetes."
Researchers have even investigated in vivo the effects of a chronic exposure to DU on vitamin D(3) metabolism, a hormone essential in mineral and bone homeostasis. Anything that affects mineral homeostasis is going to be important in setting up conditions for diabetes. This is the first time that DU was seen to depress levels of vitamin D active form and vitamin D receptor expression, and consequently could modulate the expression of vitamin D target genes involved in calcium homeostasis.
This brings up the whole point of toxicity breaking down mineral content, something that is crucial in the process of becoming much more vulnerable to the chemical onslaught. Mineral content depletion is a basic cause in diabetes and neurological disorders, it leaves the body less able to cope and eliminate toxins on a daily basis. As we shall see in the section on treatment, the depletion of normally high levels of zinc in the pancreas leaves a person more susceptible to beta cell destruction from heavy metals.
This is important to our medical review that concludes that toxic exposure to uranium is dangerous and readily provokes diabetes. In this case, we see that vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes. Vitamin D deficiency has been shown to impair insulin synthesis and secretion in humans! Furthermore, epidemiological studies suggest a link between vitamin D deficiency in early life and the later onset of type 1 diabetes. In studies on diabetic mice, pharmacological doses of vitamin D have been shown to delay the onset of diabetes, mainly through immune modulation. Vitamin D deficiency is very much involved in cancer and the outcome of treatments so again we are seeing how closely tied together are cancer and diabetes.
According to Moret, depleted uranium is the "Trojan horse of nuclear war. It is the ultimate weapon of mass destruction." The pyrophoric nature of depleted uranium causes it to burn at very low temperatures. This makes it an ideal radioactive gas weapon. "Once it gets vaporized, microscopic particles of uranium oxide remain suspended and form the radioactive component of dust."
That Trojan horse has already come to roost in Great Britain, where radiation levels, weeks after the last war in Iraq started, went up by a factor of eight from normal levels. Dr. Busby calculated that some citizens in different parts of the country would have inhaled about 26 million particles of uranium oxide. Like Troy burning, the blood in Britain's citizens is smoldering. Matt Hunt, science information manager at Diabetes UK, said: "By 2010, we estimate that the number of people with diabetes in the UK will increase by around 30 per cent to three million. Thirty percent in three years is a catastrophe."
Since the military use of DU is barely 15 years old, it is too early to know what the long term cumulative effects might be over the course of a century or more. We do know that uranium oxide particles are here to stay and that the invisible particles are suspended in the air, while some are rained out into the soil, the water, the dust; they become recycled back into the air, pervade the food chain; and often nobody can tell until years after the biological damage has been inflicted that their health or existence has been jeopardized.
On average, three times more mercury is falling from the sky today than before the Industrial Revolution. In some places it is hundreds of times higher.
It's literally raining mercury and the government is still exploding uranium weapons on American soil but the CDC is only concerned about influenza and the bird flu. Because of this they themselves are recklessly adding to our already heavy body burdens of mercury insisting we get our yearly flu shot which has about 3,000 trillion atoms of mercury in it (25 mcgs).
Thanks to the continued promotion of mercury fillings by the American Dental Association and conventional dentists, consumers continue to be poisoned by this heavy metal that's intentionally placed into their mouths. Mercury is a well documented disaster in full progress but uranium is playing catch up ball. Together with lead, arsenic and cadmium, fluoride, pesticides and a list of chemicals that would fill up a book our bodies are in the process of being overwhelmed by a sea of poisons. The tide is coming in fast but public health officials are asleep at the switch offering only red herrings to keep us confused and away from the truth. There are no effective (allopathic) agents available to induce safe excretion of retained uranium (Dr. David Quig).
Dr. Dayna Kowata wrote, "I have noticed an upward trend in uranium toxicity in my pediatric patients and not just those with autism. The effected patients come from the Temecula/Murrieta area of southern CA. One of my autistic patients has had an extremely difficult time chelating this metal. We've had success with all other heavy metals but the uranium remains consistently high. We've used oral DMSA 'and EDTA."
Nobody with any sense is supporting uranium mining and the kind of activities that turns the earth into a toxic waste dump.
Increasing levels of uranium in people's bodies changes the entire picture of chelation (removal of heavy metals from the body) thanks to the widespread use of depleted uranium weapons that are used abroad but tested at home. These are the perfect weapons of mass destruction. We are threatened from many sources of ionizing radiation including x-rays and local contamination from leaking nuclear facilities but the threat from the use of depleted uranium armaments is truly frightening.
Uranium pollution is starting to compete with mercury as a major environmental contaminant. We ignore uranium now at great risk. The vast majority of doctors do not conceive of removing heavy metals as a form of treatment of disease, so the public is in trouble and is being let down by the medical profession. Most doctors do not even do a test for heavy metals and those that do are not yet aware of the looming problem with uranium contamination. Just ask your doctor about diabetes or autism and what is causing these terrible epidemics? The chances are about zero he or she will tell you that both mercury and uranium and some other poisons are at the heart of it.
Medical scientists have struggled to explain rising rates of cancers, childhood brain disorders, diabetes and neurological conditions in both young and old alike but have fallen short of any kind of understanding that will yield helpful answers. Something about modern living has driven a steady rise of certain maladies, but they have not been able to figure out what.
Uranium levels 54.6 times the U.S. standard were found in water supplies in a village near Icheon, about 25 miles northeast of Osan Air Base, according to a South Korean government environmental report. South Korea's Ministry of Environment said it was not ready last week to release its full uranium survey of 93 sites in South Korea, but it issued a news release on its findings. Uranium levels measured 1,640 micrograms per liter in Janpyeong-ri village near Icheon.
"A recent analysis of my hair ordered by my physician indicated a uranium level that is about five times the maximum reference range. How alarmed should I be with respect to this result? I am not exposed to uranium by occupational hazard, as I'm an office manager in a very clean environment. Past ingestion may have been the result of private well water, but I've not ingested any of this well water for six years now," reports one patient.
Uranium does chelate with DMSA and EDTA chelators but NOT dramatically (Dr. Garry Gordon).
The best approaches to both mercury and uranium detoxification and chelation are natural ones. What is needed today is a radical shift in the community of doctors who do chelation mostly for neurologically damaged children and heart patients. Before even thinking of using anything that would officially bear the title of chelator of heavy metals, we and our doctors need to understand the nature of minerals (magnesium, selenium and zinc) and what they do for us to protect us from harm and what they do for us in helping us get better. The removal of heavy metals is impossible without minerals and without a full house of minerals our cells just cannot deal with the poison.
The very first thing one should do if interested in protecting themselves from the harmful effects of uranium and mercury is to start immediately with full mineralization. Iodine and magnesium are the best places to start but one should also be thinking of zinc and selenium and of course ALA. When considering children, it is helpful to know that both iodine and magnesium can be easily applied transdermally. Selenium also is vital and is the perfect antidote for mercury toxicity. Iodine is vital for the protection of our thyroid gland against radiation but in reality, when we supplement properly with this, we are strengthened in ways unimaginable to modern medicine.
The most important question of our times is: what is the safest most effective way to remove uranium,
mercury and an army of other toxins in our and our children's bodies?
For more information on the author Mark Sircus Ac., OMD, Director International Medical Veritas Association, go to:
(http://www.imva.info)
(http://www.magnesiumforlife.com)
About the author
Mark A. Sircus Ac., OMD, is director of the International Medical Veritas Association (IMVA)http://www.imva.info/. Dr. Sircus was trained in acupuncture and oriental medicine at the Institute of Traditional Medicine in Sante Fe, N.M., and in the School of Traditional Medicine of New England in Boston. He served at the Central Public Hospital of Pochutla, in M�xico, and was awarded the title of doctor of oriental medicine for his work. He was one of the first nationally certified acupuncturists in the United States. Dr. Sircus's IMVA is dedicated to unifying the various disciplines in medicine with the goal of creating a new dawn in healthcare.
He is particularly concerned about the effect vaccinations have on vulnerable infants and is identifying the common thread of many toxic agents that are dramatically threatening present and future generations of children. His book The Terror of Pediatric Medicine is a free e-book one can read. Dr. Sircus is a most prolific and courageous writer and one can read through hundreds of pages on his various web sites.
He has most recently released his Survival Medicine for the 21st Century compendium (2,200 page ebook) and just released the Winning the War Against Cancer book. Dr. Sircus is a pioneer in the area of natural detoxification and chelation of toxic chemicals and heavy metals. He is also a champion of the medicinal value of minerals and is fathering in a new medical approach that uses sea water and different concentrates taken from it for health and healing. Transdermal Magnesium Therapy, his first published work, offers a stunning breakthrough in medicine, an entirely new way to supplement magnesium that naturally increases DHEA levels, brings cellular magnesium levels up quickly, relieves pain, brings down blood pressure and pushes cell physiology in a positive direction. Magnesium chloride delivered transdermally brings a quick release from a broad range of conditions.
International Medical Veritas Association: http://www.imva.info/
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